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After following this course, the student is able to:
- Understand and explain basis concepts of host-guest chemistry and interpret experimental results
- Analyze both qualitatively and quantitatively how different molecules show different reactivity
- Write down rate equations of simple and complex reactions and use the steady state approximation
- Have a detailed knowledge of Michaelis Menten kinetics and understand the key principles of regulation of enzymatic activity
- Understand various types of acid and base catalysis.
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The properties of molecules and their reactivity strongly relate to the molecular structure. The field of Physical Organic Chemistry aims to study these correlations and learn from them. In this course, we will revisit reaction kinetics and take a deeper look at functional groups influencing reaction rates. The knowledge obtained in this course will greatly help you predicting the speed of reactions and hand you tools that you can use to influence the reaction rates (e.g. pH, catalysis, functional groups). We will also consider more complex, multistep reactions, and we will delve into enzyme kinetics. In addition, we will study the formation of host-gues complexes and other self-assembled structures. In all parts of the course, attention will be given to commonly used methods and (computational) tools used in phyiscal organic chemistry.
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