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After following this course, the student is able to:
- Understand and explain basis concepts of host-guest chemistry and interpret experimental results
- Analyze both qualitatively and quantitatively how different molecules show different reactivity and how reaction rates depend on reaction conditions
- Understand various types of acid and base catalysis.
- Write down rate equations for simple and complex (enzymatic) reactions and use the steady state approximation
- Understand the fundamentals of photochemical processes
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The properties of molecules and their reactivity strongly relate to the molecular structure. The field of Physical Organic Chemistry aims to study these correlations and learn from them. In this course, we will revisit reaction kinetics and take a deeper look at functional groups influencing reaction rates. The knowledge obtained in this course will greatly help you predicting the speed of reactions and hand you tools that you can use to influence the reaction rates (e.g. pH, catalysis, functional groups). In addition, we will study the formation of host-guest complexes and other self-assembled structures.We will also consider more complex, multistep reactions, and we will delve into enzyme kinetics. Of particular importance is the connection of reactions into (small) networks. We will analyze how reaction networks can produce a range of properties, such as oscillations, bistability, or treshold sensing, that form the basis for the molecular computation processes in living systems. In all parts of the course, attention will be given to commonly used methods and (computational) tools used in phyiscal organic chemistry.
Instructional Modes
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| You should really have a working knowledge of basic reaction kinetics of organic and enzymatic reactions and be familiar with acid-base chemistry. This is a course in the theme 'Structure and Reactivity'. |
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