NWI-MOL100
Spectroscopy of Biomolecules
Course infoSchedule
Course moduleNWI-MOL100
Credits (ECTS)3
CategoryBA (Bachelor)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; Moleculaire Wetenschappen;
Lecturer(s)
Coordinator
prof. dr. J. Oomens
Other course modules lecturer
Examiner
prof. dr. J. Oomens
Other course modules lecturer
Lecturer
prof. dr. J. Oomens
Other course modules lecturer
Contactperson for the course
prof. dr. J. Oomens
Other course modules lecturer
Lecturer
dr. R.E. van Outersterp
Other course modules lecturer
Academic year2019
Period
KW1  (02/09/2019 to 03/11/2019)
Starting block
KW1
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
After this course the student is able to:
  • explain why the internal energy of molecular systems is quantized and how this leads to optical spectra
  • calculate energy levels, transition frequencies and wave functions of simple quantized systems
  • recognize wave functions and Molecular Orbitals and explain their relation with optical spectra
  • qualitatively interpret spectra within the IR and UV/vis frequenties
  • explain the basic principles and possibilities for application of specific spectroscopic methods such as absorption, fluorescence, FRET, etc.
  • understand how IR spectroscopy leads to structural information and how electrostatic interactions determine the 3 dimensional structure of proteins
  • The student knows the theoretical background of optical spectroscopy and is able to interpret optical spectra
  • The student understands is specific spectroscopic methods such as absorption, fluorescence, FRET etc.
  • The student understands how IR spectroscopy can be used to retrieve structural information
  • The student understands how electrostatic interactions determine the three-dimensional structure of proteins and what the influence of the biological environment is
  • The student can recognize wave functions and MOs and understand how chemical bonds are formed in the MO model.
Content
The course "Spectroscopy of Biomolecules" provides insights in how fundamental quantum chemical properties lead to molecular structures and how (optical) spectroscopy can be used to investigate these proporties. Starting from a basic understanding of energy quantization, the corresponding wave functions and the hydrogen atom, the molecular bonds in the molecular orbital model are discussed and how they give rise to specific transitions in the vibrational and electronic spectra. These concepts are applied to the molecular structure of biological molecules, in particular peptides and proteins.
Level

Presumed foreknowledge
Atoom en molecuulbouw (NWI-MOL079), Wiskunde 1-3 (NWI-MOL004, NWIMOL009, en NWI-MOL015), Spectroscopische technieken (NWI-MOL019). Dit is een cursus in de leerlijn 'Moleculaire levenswetenschappen'.
Test information
Schriftelijk tentamen
Specifics

Topics
• chemical bonds, MO-model and wave functions
• energy levels of (bio) molecules
• optical spectroscopy: vibrational (IR) and electronic (UV) spectroscopy
• structure of proteins on the basis of electrostatic interaction
• specific spectroscopic methods in order to determine the structure of biomolecules

Test information
Written exam

Prerequisites
Atoom en molecuulbouw (NWI-MOL079), Wiskunde 1-3 (NWI-MOL004, NWIMOL009, and NWI-MOL015), Spectroscopische technieken (NWI-MOL019). This is a course in the programme 'Molecular life sciences'.

Recommended materials
Book
P. Atkins & J. de Paula, Physical Chemistry for the Life Sciences.
ISBN:9780199564286

Instructional modes
Lecture
Attendance MandatoryYes

Tutorial
Attendance MandatoryYes

Tests
Tentamen
Test weight1
Test typeExam
OpportunitiesBlock KW1, Block KW2