|Language of instruction||English|
|Offered by||Radboud University; Faculty of Science; Moleculaire Wetenschappen; |
|KW1|| (04/09/2017 to 12/11/2017)|
|Registration using OSIRIS||Yes|
|Course open to students from other faculties||Yes|
|Placement procedure||After an intake interview|
|Explanation||After an intake interview|
At the end of the course you are able to:
- describe general molecular and cellular principles of biotechnology
- describe the application of biotechnology to prevent, diagnose or treat human disease
- identify recent developments in medical biotechnology
- design new strategies to use medical biotechnology in clinical practice
- recognize and evaluate ethical, regulatory and societal aspects of biotechnology in medicine
- work and collaborate effectively in a group
- effectively communicate scientific information orally and in writing
Medical biotechnology is the application of living cells or cell material in the development or generation of products to prevent, diagnose or treat human disease. Historical examples of biotechnology in support of medicine are the development of vaccines against smallpox and the production of antibiotics or human insulin by bacteria or yeast. Exciting 21st century developments are genetic engineering, gene therapy and stem cell-based regenerative medicine. Medical biotechnology is a rapidly evolving field integrating knowledge obtained in molecular, cell biological, genetic and immunological scientific areas.|
Through this course, you will obtain an overview of how interdisciplinary efforts help shaping modern healthcare by developing biotechnological diagnostics and therapeutics for precision medicine. Principles and concepts of medical biotechnology will be discussed in a scientific and societal context, including ethical and legal considerations. Together with fellow-students you will use this knowledge and write a medical biotechnological research proposal and present this during a mini-symposium. Medical Biotechnology towards Clinical Practice presents an excellent foundation for students interested in molecular life sciences in relation to modern clinical practice.
Recombinant therapeutics, genetic engineering, gene therapy, vaccines, molecular diagnostics, biologics, stem cells, regenerative medicine, tissue engineering, immunotherapy, medical ethics
|This course builds on background information in:|
• Lodish et al., Molecular Cell Biology, 7th ed.
• Griffiths et al., Introduction to Genetic Analysis, 10th ed.
• Abbas et al., Cellular and Molecular Immunology, 7th ed.
Links to additional study material (reviews, primary research papers) will be provided via Blackboard.
|• 22 hours Lectures|
• 10 hours Interactive Lectures / question sessions
• 06 hours Computer practicals
• 48 hours Group project work without guidance
• 06 hours Tutor sessions
• 04 hours Student Presentations
• 60 hours individual self study
|NWI-MOL104 is identical to the first half of the (Radboudumc) minor MED-MIN13 for Biomedical Sciences students. Hence, the course will take place on Radboudumc premises. Maximally 24 BMS students will be admitted, leaving at least 24 (and maximally 48) slots available for Molecular Life Sciences and (Medical) Biology students. Application deadline is July 31, 2017.|
In case the number of applications exceeds the available positions, a selection will be made by the coordinators in August 2017. Selection will be based on motivation and commitment.
Therefore, to increase chance for admission, FNWI students are invited to send a letter of motivation and commitment to the coordinators before August 1, 2017.
|• Advanced cloning, engineering and genetic modification|
• Antibodies, vaccines, immunotherapy
• Gene therapy and genetic therapy
• Stem cell therapy and regenerative medicine
• Ethical, legal, economical and societal perspectives
|Assessment consists of four parts (each must be graded at least 5.5 to pass the course):|
• Written exam (individual; total weight 40%)
• Written mini-review and research proposal (group; weight 40%)
• Oral presentation of research proposal (group; weight 10%)
• Performance, initiative, input and participation during the course (individual; weight 10%)
|Knowledge obtained in the courses “Celbiologie der Dieren” and “Biochemistry & Molecular Biology II” is required.|
In view of the maximal number of students that can be dealt with in the course, a selection procedure may be conducted (see "Additional comments" above).
|Dr. Wiljan Hendriks (email@example.com) and Dr. Rick Wansink (firstname.lastname@example.org), Department of Cell Biology (283), Radboudumc|
|Literature and additional material provided via Blackboard|
|Lodish et al., Molecular Cell Biology, 7th ed., McMillan Higher Education/ W.H.Freeman & Company|
|Griffiths et al., Introduction to Genetic Analysis, 10th ed|
|Abbas et al., Cellular and Molecular Immunology, 7th ed|
GeneralBased on the lecture, background literature and assignments (to be found in the Course Manual), discussions on the subject will be held and clarifications will be given.
Preparation of meetingsPrepare by answering the accompanying questions (listed in the Course Manual)
GeneralPlease note that the lectures most likely will NOT be recorded. Handouts of the lectures will be published on Blackboard, and accompanying articles are listed in the Course Manual.
|Practical computer training|
GeneralBy means of computer-assisted educational means (E-learning modules) you will learn more about i) Biochemical and Cell Biological Techniques, ii) Rec-DNA and Recombinant Proteins, and iii) Genetically Modified Organisms.
|Presentations / Minisymposium|
GeneralDuring this afternoon all student teams will present their research proposal. At the end of the symposium your peers will elect the best project.
GeneralAs a team (3-5 students) you design, write down and present a PhD research proposal.
Guidance via tutor meetings will be provided.
RemarkIn total: 48 h, 2880 min
RemarkIn total: 3600 min, 60 h
|Tutor group meeting|
GeneralDuring six meetings with the Tutor, the team will discuss in-depth items relating to the writing of the Research Proposal.
Preparation of meetingsTutors need to be provided, well in advance, with meeting agenda and relevant teamwork products.
|Opportunities||Block KW1, Block KW3|