 | | | | | Cursus | | NWI-MOL104 | | Categorie | | BA (Bachelor) | | Voertaal | | Engels | | Aangeboden door | | Radboud Universiteit; Faculteit der Natuurwetenschappen, Wiskunde en Informatica; Moleculaire Wetenschappen; | | Docenten | | | | | Collegejaar | | 2022 | | | Periode | | | KW1 | (05-09-2022 t/m 06-11-2022) |
| | Aanvangsblok | | | KW1 | |
| | Onderwijsvorm | | | voltijd | |
| | Opmerking | | Motivation letter necessary. Everyone will be placed on a waiting list first. | | Inschrijven via OSIRIS | | Ja | | Inschrijven voor bijvakkers | | Ja | | Voorinschrijving | | Nee | | Wachtlijst | | Ja | | Plaatsingsprocedure | | Handmatig door Administratie | | Toelichting | | Handmatig door Administratie |
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By the end of this course, you will be able to
1 - describe molecular and cellular principles of biotechnology
2 - describe the application of biotechnology to prevent, diagnose or treat human disease
3 - identify new developments in medical biotechnology
4 - design new strategies to use medical biotechnology in clinical practice
5 - recognize and evaluate ethical, regulatory and societal aspects of biotechnology in medicine
6 - work and collaborate effectively in a group
7 - effectively communicate scientific information orally and in writing
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Medical biotechnology comprises the application of living cells or cell material in the development or generation of products to prevent, diagnose or treat human disease. Historical examples of biotechnology in support of medicine are the development of vaccines against smallpox and the production of antibiotics or human insulin by bacteria or yeast. Exciting 21st century developments are genetic engineering with CRISPR/Cas, gene therapy, mRNA vaccines against COVID-19 and stem cell-based regenerative medicine. Medical biotechnology is a fascinating and rapidly evolving field, integrating molecular, cell biological, genetic and immunological research areas.
Through this course, you will obtain an overview of how interdisciplinary efforts help shaping modern healthcare by developing biotechnological diagnostics and therapeutics for precision medicine. Principles and concepts of medical biotechnology will be discussed in a scientific and medical context, including legal, societal and ethical considerations. Together with students from different life sciences disciplines (see further below) you will write a medical biotechnological research proposal and present this at a mini-symposium.
Altogether, Medical Biotechnology presents an excellent course for students interested in molecular life sciences and in biotechnological innovations for patient care.
Key words
Recombinant therapeutics, genetic engineering, CRISPR/Cas9, gene therapy, vaccines, molecular diagnostics, biologics, stem cells, regenerative medicine, tissue engineering, immunotherapy, medical ethics
Teaching methods
- 30 hours (interactive) lectures
- 4 hours computer practicals
- 4 hours symposium (oral presentations)
- 5 hours tutor meetings (research proposal)
- 48 hours team work (mini-review, research proposal)
- 50 hours self study (including assignments and literature study)
The course language is English.
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The course builds on knowledge obtained in courses like MOL127, MOL027 and MOL158 (MLS) or BP007, BP010, BP032 and BB091 (Biol). Knowledge obtained in electives MOL113, BB017 and/or BB019 will be of great help as well.
Application deadline is July 31, 2022. In view of the maximal number of students that can participate in the course, a selection procedure is conducted (see Extra information below).
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Assessment consists of four parts (each must be graded at least 5.5 to pass the course):
- Written exam (individual; total weight 40%)
- Written mini-review and research proposal (group; weight 40%)
- Oral presentation of research proposal (group; weight 10%)
- Performance, initiative, input and participation during the course (individual; weight 10%)
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NWI-MOL104 is identical to the first half of the Radboudumc minor MED-MIN13 Medical Biotechnology towards Clinical Practice for Biomedical Sciences and Medical students. Yearly some 15 Radboudumc students participate in the minor. This means that generally some 30 slots are available for Molecular Life Sciences and (Medical) Biology students.
Application deadline is July 31, 2022. A selection based on motivation will be made by the coordinator in August 2022. Science faculty students should therefore also send a letter of motivation to the deputy course coordinator via Email (wiljan.jaj.hendriks@radboudumc.nl), July 31 at the latest.
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| | | Verplicht materiaalDigitale leeromgeving (Brightspace)| Links to additional study material (reviews, primary research papers) will be provided via Brightspace. |
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Aanbevolen materiaalBoek| Lodish et al., Molecular Cell Biology, 8th ed., McMillan Higher Education/ W.H.Freeman & Company |
| ISBN | : | | 9781464187445 |
| Boek| Griffiths et al., Introduction to Genetic Analysis, 11th ed |
| ISBN | : | | 978-1464109485 |
| Boek| Abbas et al., Cellular and Molecular Immunology, 9th ed |
| ISBN | : | | 9781437715286 |
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WerkvormenInteractive Lectures
AlgemeenBased on the lecture, background literature and assignments (to be found in the Course Manual), discussions on the subject will be held and clarifications will be given.
Voorbereiding bijeenkomstenPrepare by answering the accompanying questions (listed in the Course Manual)
OpmerkingIn total: 9 h
| Lectures
AlgemeenPlease note that the lectures most likely will NOT be recorded. Handouts of the lectures will be published on Brightspace, and accompanying articles are listed in the Course Manual.
OpmerkingIn total: 20 h
| Minisymposium (student presentations)| Aanwezigheidsplicht | | Ja |
AlgemeenDuring this afternoon all student teams will present their research proposal. At the end of the symposium your peers will elect the best project.
OpmerkingIn total: 4 h
| Practical computer training| Aanwezigheidsplicht | | Ja |
AlgemeenBy means of computer-assisted educational means (E-learning modules) you will learn more about i) Rec-DNA and Recombinant Proteins, and ii) Genetically Modified Organisms.
OpmerkingIn total: 4 h
| Project (team work)| Aanwezigheidsplicht | | Ja |
AlgemeenAs a team (3-5 students) you design, write down and present a PhD research proposal.
Guidance via tutor meetings will be provided.
OpmerkingIn total: 48 h
| Self Study
OpmerkingIn total: 50 h
| Tutor group meeting| Aanwezigheidsplicht | | Ja |
AlgemeenDuring six meetings with the Tutor, the team will discuss in-depth items relating to the writing of the Research Proposal.
Voorbereiding bijeenkomstenTutors need to be provided, well in advance, with meeting agenda and relevant teamwork products.
OpmerkingIn total: 5 h
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ToetsenTentamen| Weging | | 4 |
| Toetsvorm | | Tentamen |
| Gelegenheden | | Blok KW1, Blok KW2, Blok KW3 |
| Schrijfopdracht| Weging | | 4 |
| Toetsvorm | | Opdracht |
| Gelegenheden | | Blok KW1 |
| Presentatie| Weging | | 1 |
| Toetsvorm | | Presentatie |
| Gelegenheden | | Blok KW1 |
| Participatie| Weging | | 1 |
| Toetsvorm | | Deelname |
| Gelegenheden | | Blok KW1 |
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