At the end of the course you can:
- Understand basic concepts of biophysical chemistry in the context of living cell and interpret experimental results
- Understand and apply theoretical and practical aspects of single-molecule approaches used in bio(nano)scienceUnderstand biological mechanics:
- Analyze how molecular forces of biopolymers and molecular machines are used in cellular function.
- Analyze both qualitatively and quantitatively how biomolecules move and interact to drive biological processes
- Write a report based on practical and scientific publications related to the course contents
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Biophysical chemistry, often referred to as biophysics or physical biology, deals with biomacromolecules and complexes. The sophisticated interplay between molecular forces and chemical energy make reactions in living cells work. The discipline is highly multidisciplinary and the principles and concepts are drawn from chemistry, physics and biology. The field has huge potential and is fundamental for many other fields. Molecular motors found in cells are an inspiration for nanotechnology. The biopolymers and membranes from which they are constructed are an inspiration for materials science. Recently there has been an explosion of beautiful new results of molecular motors, self-assembly, the influence of molecular crowding and compartmentalization, single-molecule manipulation and imaging that have revolutionized the field. This course aims to uncover some of the fundamental biophysical concepts that are used to model and understand these complicated processes. The course is meant for molecular sciences students with a keen interest in biological physics and quantitative biology.
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A basic knowledge of mathematics, thermodynamics, biochemistry and reaction kinetics as acquired in earlier stages of the curriculum.
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A report based on practical (20%) and a written exam (80%).
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Students who need a resit of the course given by dr. Heus in 2021, please contact him as soon as possible: h.heus@science.ru.nl
Contact: Dr. J.M. Eeftens, tel. 3610560, jorine.eeftens@ru.nl.
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