Chemical Analysis 1
Course infoSchedule
Course moduleNWI-MOL121
Credits (ECTS)3
CategoryPB (Propaedeutic)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; Moleculaire Wetenschappen;
K.K.W. van Asseldonk, MSc
Other course modules lecturer
dr. T.G. Bloemberg
Other course modules lecturer
dr. T.G. Bloemberg
Other course modules lecturer
dr. T.G. Bloemberg
Other course modules lecturer
Contactperson for the course
dr. T.G. Bloemberg
Other course modules lecturer
Academic year2020
KW1  (31/08/2020 to 01/11/2020)
Starting block
Course mode
Registration using OSIRISYes
Course open to students from other facultiesYes
Waiting listNo
Placement procedure-
After this course, you are able to:
  • interpret the results of basic analytical chemical experiments using the appropriate statistical methods. 
  • explain - at a basic level - the interactions of electromagnetic radiation with atoms and molecules and exploit these in simple quantitative spectroscopic analyses.
  • explain the basics of chromatographical separation and detection techniques and interpret chromatograms.
  • interpret and predict the IR, NMR and mass spectra of simple organic molecules.
  • Mean, standard deviation, confidence intervals, significant figures, error propagation, calibration, linear regression, internal standard, standard addition.  
  • The Beer-Lambert law, absorption – excitation – emission, energy levels, molecular vs. atomic UV-Vis spectra, single-beam and double-beam spectrometers, fluorescence spectroscopy, polarimetry.  
  • Extraction, multiplicative extraction, LC, GC, TLC, band broadening, types of LC, GC vs. distillation, column types, injection, HPLC, mobile and stationary phases, eluent strength, gradient elution, GC and LC detectors, mass spectrometer as detector. 
  • IR: infrared radiation, vibration modes, group frequency region and fingerprint region, frequently occurring peaks, practicalities of IR measurements. 
  • NMR: radiofrequency radiation, magnetic fields, spin states, chemical shift, number of peaks, peak integrals, multiplets for weakly coupled systems, deuterated solvents. 
  • MS: electron ionization, molecular ion, base peak, fragmentation, isotopes, typical fragmentation patterns, McLafferty rearrangement, ‘rule of 13’, ‘logical losses’, nitrogen rule. 
Instructional Modes
This course will focus on you keeping up with reading the books and support you in that using a variety of tools:
  • a weekly set of basic questions on Brightspace
  • so-called 'knowledge clips' that become available after having answered these questions correctly
  • weekly tutorials with more advanced problems and exercises
  • a weekly Q&A session combined with topical examples
  • some computer practicals
Presumed foreknowledge
Chemistry at the level of Dutch pre-university secondary education ('VWO') or comparable
Test information
The digital exam will consist of two parts: a relatively easy first part, and a second part of regular difficulty. If the first part results in a 5.5 or lower, the rest of the exam will not be graded. The grade for the first part does not contribute to the final grade. Grading will be in accordance with RU standards, on a scale of 1 to 10. The final grade is rounded to the nearest half, with the exception of grades between 5.0 and 6.0 which are rounded to the nearest integer. Grades of 6 and higher are considered a 'pass' and grades lower than 6 are considered a 'fail'.
Required materials
D.C. Harris, Quantitative Chemical Analysis, 10th ed., 2020, W.H. Freeman and Company, New York
Paula Y. Bruice, Organic Chemistry, 8th ed., Pearson Education Ltd., Harlow, England
Microsoft Excel 2016 or newer

Recommended materials
T. Overton, S. Johnson, J. Scott: Study and communication skills for the chemical sciences, 3rd ed., Oxford University press

Instructional modes

Practical computer training


Digital Exam
Test weight1
Test typeDigital exam with CIRRUS
OpportunitiesBlock KW1, Block KW2, Block KW4