After this course the student is able to:
- apply bioinformatics methods to biological, (bio)chemical and biomedical problems.
- consult bioinformatic databases via the WWW.
- analyse protein sequenties that were found, make a (multiple) sequence alignment from these and deduce properties of one protein from known properties of other proteins.
- apply knowledge of special properties of amino acids and the way these determine properties of proteins to biological, (bio)chemical and biomedical problems.
- predict the secundary structures of proteins and use these in solving questions related to protein sequence.
- partake in the followup courses: Structure, Function, Bioinformatics (MOL066) (macromolecular structures), Comparative Genomics (MOL073) (genomics) and Chemical Discovery and Design (CMBI101B).
- Use of databases and database search software. Sound knowledge of amino acids, their physical and chemical properties, and the relation between these properties and the structure and function of the protein as a whole.
- Understanding of the significance of the results of sequence comparisons.
- Prediction of secondary structures and the use of this predicted secundary structure in solving questions related to protein sequence.
- Use of multiple sequence alignment software and the interpretation if its results.
- Use of detected sequence homologues, and (sequence) databases and software for information retrieval of as yet uncharcterised proteins.
This course will be graded by both a normal written exam and a group-project. |
Also, a mid-term digital amino acid exam will take place using Cirrus.
Full participation during the practicals is required. A standard day in this course starts with a short response seminar to discuss the previous day, followed by a seminar with new information. This new information will be applied during the practical computer work, scheduled for the remainder of the day. Experience has shown us that those students that actively participate during the practicals score much higher on their exams.