Course module NWI-MOL403 Credits (ECTS) 3 Category MA (Master) Language of instruction English Offered by Radboud University; Faculty of Science; Moleculaire Wetenschappen; Lecturer(s) Lecturer dr. T.J. Boltje Other course modules lecturer Lecturer dr. D.W.P.M. Löwik Other course modules lecturer Coordinator dr. D.W.P.M. Löwik Other course modules lecturer Contactperson for the course dr. D.W.P.M. Löwik Other course modules lecturer Academic year 2017 Period KW1   (04/09/2017 to 12/11/2017) Starting block KW1 Course mode full-time Remarks - Registration using OSIRIS Yes Course open to students from other faculties Yes Pre-registration No Waiting list No Placement procedure -

	Aims Be able to apply naming conventions Be able to apply protective groups in an organic synthesis Be aware of the main concerns synthesizing biomolecules Have knowledge of the chemistry required to plan a synthesis of peptides, carbohydrates and DNA Make a motivated choice between a solid phase and solution phase strategy Devise a chemical (semi)-synthesis of a large protein Understand how to introduce selective modifications and construct conjugates of biomolecules Content This course aims to provide an organic chemistry basis for the track Chemical Biology but is open to all Chemistry and MLW students. The student is provided with a broader look on the organic chemistry of bio-molecules. In addition to the chemical synthesis of peptides/proteins, carbohydrates and DNA/RNA topics like protective group strategy, solid phase chemistry, chemoselective modifications and conjugation chemistry will be covered as well as some structural and analytical aspects. Literature • handouts and syllabus Recommended: • B. G. Davis and A.J. Fairbanks, Oxford Chemistry primers, Carbohydrate Chemistry, Oxford University Press; • J. Jones, Oxford Chemistry primers, Amino Acid and Peptide Synthesis, Oxford University Press Teaching formats • 32 hours lecture • 52 hours individual study period Topics • chemical synthesis of peptides/proteins • carbohydrates • DNA/RNA • protective group strategy • solid phase chemistry • chemoselective modifications • conjugation chemistry • structure and analysis of biomolecules Test information written exam (80%) + presentation (20%) Prerequisites Bachelor SK/MLW/Sc (preferably Atoom- en Molecuulbouw (NWI-MOL079), Moleculaire structuur (NWI-MOL080), Reacties en Kinetiek (NWI-MOL007), Biomoleculen (NWI-MOL008), Synthese biomoleculen (NWI-MOL047), Organische chemie (NWI-MOL095)) This is a mandatory course in the specialisation 'Chemistry for Life'.
	Required materials Reader Handouts and Syllabus Recommended materials Book B. G. Davis and A.J. Fairbanks, Oxford Chemistry primers, Carbohydrate Chemistry, Oxford University Press Book J. Jones, Oxford Chemistry primers, Amino Acid and Peptide Synthesis, Oxford University Press Instructional modes Lecture Tutorial Zelfstudie Tests Tentamen Test weight 1 Test type Exam Opportunities Block KW1, Block KW2