In this course, the role of interfaces in chemistry are considered and you will learn why and how chemistry and molecular processes at interfaces are different from bulk solution. By taking an interdisciplinary, quantitative approach you will gain insight into many (bio)chemical systems, in which interfaces play an important role, ranging from cell membranes to organic solar cells. At the end of this course, you will have:
- gained a general understanding of interfacial properties and their characterization,
- learned to understand and quantify interfacial interactions and phenomena,
- obtained a basic understanding of reaction kinetics and catalysis at surfaces,
- become familiar with the various types of biointerfaces: inside cells and between cells and materials,
- obtained a quantitative understanding of the dynamics of transport across membranes and applications based on this process.
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Interfaces play a crucial role in many chemical processes and biological systems. Cells are bound by membranes across which every molecule is transported. Products we use in our daily lives, such as ink, mayonnaise and wine, would not look, feel and taste the same without stabilization of their interfaces. And many renewable energy technologies rely on chemical reactions taking place at an interface. Understanding why and how chemistry and molecular processes at interfaces are different from bulk solution is essential for many studies of living systems and functional materials.
In this course a detailed overview of interfacial phenomena, interactions and reactions will be given. This course deals with both abiotic and biological interfaces, and aims to deliver a generic understanding of interfacial chemistry and biophysics from a molecular point of view. In particular, we will discuss surface forces, the kinetics of reactions at surfaces, molecular signaling and transport processes across membranes, and we will learn how a better understanding of these aspects can lead to the development of new catalysts, smart biosensors and functional synthetic tissues.
Instructional Modes
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This course aims at master students Molecular Sciences (Chemistry, Molecular Life Sciences, and Science). A basic background in physical organic chemistry is expected. This is an elective course in the specializations 'Chemistry of Life', 'Medicinal Chemistry', 'Molecular Chemistry' and 'Physical Chemistry'.
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Written exam (75%) and scientific referee report (25%).
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Literature: Lecture notes, reader, handouts and selected articles Optional / suggested books for further reading:
- Physical Biology of the Cell by R. Phillips, J. Kondev, J. Theriot and H.G. Garcia, ISBN 978-0-8153-4450-6 (note: this book also used in NWI-SM296: Physical Organic Chemistry of the Cell)
- Physical Chemistry of Surfaces by A.W. Adamsom and A.P. Gast, ISBN 978-0-471-14873-3
- Physics and Chemistry of Interfaces by H.-J. Butt, K. Graf and M. Kappl, ISBN 978-3-527-40629-6
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