- Students can describe and compare different high-resolution neurophysiological techniques, and understand the strengths and limitations of the different techniques
- Students can motivate why a particular technique will be preferred for a given research question
- Students can interpret neural responses to sensory stimuli and behavioural responses obtained with the different techniques
- Students understand the physical-chemical principles of electrophsyiological recordings, of two-photon neuroimaging, and of optogenetics.
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The course provides conceptual, methodological, and practical insights into the major high-resolution neurophysiological techniques that are used to probe and manipulate the function of local neural circuits in vivo and in vitro preparations, such as single-unit recordings, micro-stimulation, and local inactivation, patch clamping, multi-electrode recording arrays (MEA’s) and multi-unit data analysis (Battaglia), two-photon microscopy (Van Wezel), and optogenetics (Tiesinga).
Each method is explained in a 2 hr lecture, and illustrated by a key research paper, and covered in a two-hour computer practicum, in which experimental results obtained with the method are analysed and interpreted by the students as assignments (and a written report). |
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| Neurofysica 1 (WiNSt, Science), or Neurobiofysica (Bi), or equivalent
Systems Neuroscience (Master), Behavioural Neuroscience (Master) |
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| Written exam (70%) and brief essays on results of computer practica (30%) |
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| This course is obligatory for all students enrolled in the FNWI Neuroscience Master Track.It is also open as an elective course for students from the Cognitive Neuroscience Research Master (track 4: Brain Networks and Neuronal Communication, and track 2: Perception, Action, and Control). |
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