- At the end of this course the student understands the basic theory behind modern NMR techniques in fields ranging from structural biology to materials science.
- On the basis of this knowledge he/she can predict the outcome of NMR pulse sequences employed in modern liquid state NMR of moderately complex spin systems
- The student recognizes the basic manifestations of single crystal and powder NMR spectra in the solid-state and can extract and interpret the interaction parameters contained in the spectra
- The student recognizes the basic manifestations of molecular motions and preferential alignments on NMR spectra
- The student can describe the effect of crystal rotations and magic angle spinning on the various NMR interactions
- The student can propose basic NMR sequences to extract specified structural or dynamic information for moderately complex spins systems
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This course treats the basics of state-of-the-art NMR techniques. Various topics will be treated in view of advanced applications of NMR in Life Science and Materials Science. The themes that will be addressed are:
- Reprise: Larmor precession, rotating frame, Bloch equations
- Basic NMR hardware and principle of the measurement
- The density operator concept, QM approach of the rotating frame
- The Operator Formalism, in order to be able to analyze the effect of NMR pulse sequences on coupled spin system
- The nuclear spin Hamiltonian and its spectral manifestation in liquids, liquid crystals (alignment), single crystals and powders
- Use of spherical tensor operators
- Motion (coherent and incoherent): averaging, exchange
- The mechanisms of spin-spin and spin-lattice relaxation
- Multi-dimensional NMR
- Phase cycling, coherence selection, canceling unwanted signals
Instructional Modes
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Quantum Mechanics (MOL155)/Quantum Mechanics 1 & 2 (MOL041 & MOL046), Magnetic Resonance in Chemistry (NWI-MOL108), Applied Magnetic Resonance (NWI-MOL110), or Magnetic Resonance I (MOL057)
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Mid-term and end examination (written exams, open book).
Grade is determined by the average of both exams.
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Please note that his course starts in the 2nd quarter, but will be continued in quarter 3. Scheduling of lectures and problem sessions will take place in consultation with the students. |
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