NWI-SM302
Advanced Organic Synthesis
Course infoSchedule
Course moduleNWI-SM302
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; Moleculaire Wetenschappen;
Lecturer(s)
Coordinator
dr. D. Blanco Ania
Other course modules lecturer
Examiner
dr. D. Blanco Ania
Other course modules lecturer
Contactperson for the course
dr. D. Blanco Ania
Other course modules lecturer
Lecturer
dr. D. Blanco Ania
Other course modules lecturer
Lecturer
prof. dr. F.P.J.T. Rutjes
Other course modules lecturer
Academic year2021
Period
KW1  (06/09/2021 to 07/11/2021)
Starting block
KW1
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
After the course, you are able to:
  • solve independently and critically organic synthetic problems that you may come across during the master program in organic chemistry,
  • formulate the mechanisms of important and complex reactions in organic chemistry and predict their regio-, stereo- and enantioselectivity,
  • design three/four-step synthesis of small molecules,
  • identify and reproduce often applied name reactions,
  • discuss and analyze organic chemistry literature and report with the proper chemical nomenclature.
Content
The main focus of the Advanced Organic Synthesis course is to lift organic chemistry mechanisms and principles from a passive knowledge and perception to a level of thorough understanding and active application. To this end, you will be taught to solve organic chemistry problems by combining an increasing knowledge of organic chemistry principles with chemical logic. The instructor will help you whenever necessary, both in classical classroom form and on an individual basis.
This learning involves a thorough repetition of the most important contemporary organic chemistry transformations. A list of name reactions will be provided containing reactions that are supposed to be known and popular reactions that will be discussed in detail. Further specific contents of the course will be highly dynamic, based on recent literature. After this course (and combined with the corresponding practical internship), the students should be able to work independently at a chemical or pharmaceutical company and propose solutions to synthetic problems they might encounter.

Instructional Modes

Topics:
  • Oxidations of alcohols to aldehydes and ketones and reduction of aldehydes and ketones to alcohols
  • Radical reductions and [3,3] sigmatropic rearrangements
  • Chemistry of imines, iminium ions and nitrilium ions
  • Oxidations of alkenes: dihydroxylation, aminohydroxylation and epoxidation
  • Palladium-catalyzed cross-coupling reactions
  • Substitution reactions
  • Chemistry of carbenes and carbenoids and 1,3-dipolar cycloaddition reactions
 
Level
Master's course. Advanced.
Presumed foreknowledge
'Structure of Atoms and Molecules' (NWI-MOL120), 'Organic Chemistry 1' (NWI-MOL124), and 'Organic Chemistry' (NWI-MOL095) (all compulsory). 'Metal Organic Chemistry' (NWI-MOL096) (elective) and 'Stereoselective Synthesis' (NWI-MOL093) (recommended). This is a mandatory course in the specialisation 'Molecular chemistry'.
Test information
Assignment(s) 20% (minimum 5.5) + (final) written exam 80%
Specifics

Required materials
Articles
Scientific articles
Reader
Fundamental Organic Chemistry (the 'Red Booklet'; Blanco-Ania, D.; van Delft, F.; Verkade, J.; 5th edition, 2015) containing a summary of name reactions in basic organic chemistry will be provided at the first session.
Title:Fundamental Organic Chemistry
Author:Blanco-Ania, D.; van Delft, F.; Verkade
Edition:5
Costs:0.00

Instructional modes
Lecture
Attendance MandatoryYes

Tutorial
Attendance MandatoryYes

Tests
Exam
Test weight4
Test typeExam
OpportunitiesBlock KW1, Block KW2

Assignments
Test weight1
Test typeAssignment
OpportunitiesBlock KW1