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After the course, you are able to:
- solve independently and critically organic synthetic problems that you may come across during the master program in organic chemistry,
- formulate the mechanisms of important and complex reactions in organic chemistry and predict their regio-, stereo- and enantioselectivity,
- design three/four-step synthesis of small molecules,
- identify and reproduce often applied name reactions,
- discuss and analyze organic chemistry literature and report with the proper chemical nomenclature.
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The main focus of the Advanced Organic Synthesis course is to lift organic chemistry mechanisms and principles from a passive knowledge and perception to a level of thorough understanding and active application. To this end, you will be taught to solve organic chemistry problems by combining an increasing knowledge of organic chemistry principles with chemical logic. The instructor will help you whenever necessary, both in classical classroom form and on an individual basis.
This learning involves a thorough repetition of the most important contemporary organic chemistry transformations. A list of name reactions will be provided containing reactions that are supposed to be known and popular reactions that will be discussed in detail. Further specific contents of the course will be highly dynamic, based on recent literature. After this course (and combined with the corresponding practical internship), the students should be able to work independently at a chemical or pharmaceutical company and propose solutions to synthetic problems they might encounter.
Instructional Modes
Topics:
- Oxidations of alcohols to aldehydes and ketones and reduction of aldehydes and ketones to alcohols
- Radical reductions and [3,3] sigmatropic rearrangements
- Chemistry of imines, iminium ions and nitrilium ions
- Oxidations of alkenes: dihydroxylation, aminohydroxylation and epoxidation
- Palladium-catalyzed cross-coupling reactions
- Substitution reactions
- Chemistry of carbenes and carbenoids and 1,3-dipolar cycloaddition reactions
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Master's course. Advanced.
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'Structure of Atoms and Molecules' (NWI-MOL120), 'Organic Chemistry 1, 2 and 3' (NWI-MOL124, NWI-MOL161, NWI-MOL095) (all compulsory).
'Metal Organic Chemistry' (NWI-MOL096) (elective) and 'Stereoselective Synthesis' (NWI-MOL093) (recommended). This is a mandatory course in the specialisation 'Molecular chemistry'.
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| Assignment(s) 20% (minimum 5.5) + (final) written exam 80% |
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