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Cursus: NWI-BB086
NWI-BB086
Genomics for Health and Environment
Cursus informatieRooster
CursusNWI-BB086
Studiepunten (ECTS)12
Categorie03 (Verdiepend)
VoertaalEngels
Aangeboden doorRadboud Universiteit; Faculteit der Natuurwetenschappen, Wiskunde en Informatica; BioWetenschappen;
Docenten
Docent
dr. A. Hoischen
Overige cursussen docent
Examinator
dr. C. Logie
Overige cursussen docent
Docent
dr. C. Logie
Overige cursussen docent
Coördinator
dr. C. Logie
Overige cursussen docent
Contactpersoon van de cursus
dr. C. Logie
Overige cursussen docent
Collegejaar2023
Periode
KW1  (04-09-2023 t/m 05-11-2023)
Aanvangsblok
KW1
Onderwijsvorm
voltijd
OpmerkingMaximum capacity: 45. Course coordinator controls enrolment
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersNee
VoorinschrijvingJa
Voorinschrijving geopendvanaf - t/m -
WachtlijstJa
PlaatsingsprocedureHandmatig door Administratie
ToelichtingHandmatig door Administratie
Cursusdoelen
Learning outcomes: At the end of the course you can:
  • conduct nucleic acid isolation and library preparation for the major next-generation DNA sequencing machines in a small team 
  • use the Bash shell to navigate directory structures, manipulate files and execute commands in an automated manner
  • identify functionally relevant genetic variation in genes
  • define the human microbiome and explain the role metagenomics plays in its investigation
  • define the transcriptome and explore its features
  • define human genetic variation
  • explore metabolic and signal transduction pathways
  • report on your next generation sequencing research findings in a public talk
  • reflect on ethical questions and implications pertaining to next generation sequencing applications in medicine and ecology.

 
Inhoud
The general objective is to provide students with theoretical background and hands-on experience in microbial (meta)genomics, medical genomics and transcriptomics.  Bioinformatic aspects of genome complexity, read mapping, next generation DNA sequencing (NGS) signal quantification and functional interpretation are taught.
There is a 3 week long department-specific full time practical component to this course, split across the Microbiology (FNWI), Human  Genetics (UMCN) and Molecular Biology (FNWI) departments. During this practical you will perform research in groups of 3 students together with researchers from one of the departments, working with them on their ongoing research topic. Hence GHE students are exposed to state-of-the-art research practice. Students from each practical group report their findings during a two-day symposium which also hosts international speakers.

Instructional Modes
  • Tutorial
  • Response course
  • Presentation
  • Self-study
Niveau

Voorkennis
Required:
  1. Genetics and molecular biology
    1. BP010C - or equivalent;
    2. Desirable: BB017C or BP031, or equivalent
  2. Biochemistry
    1. BP007C or MOL129, or equivalent
  3. Microbiology
    1. BP033 or equivalent, or more advanced microbiology course(s)
Toetsinformatie
The final mark is determined for 55% by the Final exam, 15% Essay, 10% Practical report, 10% Practical work and 10% for Final symposium presentation. Minimum grade for all parts is 5.5. 
Bijzonderheden
Participation is limited to 45 students who must register personally through the course coordinator (clogie@science.ru.nl) in May and June. If more than 45 applications are received by mid-June, a stratified random drawing proportional to the number of applications emanating from Biologists/MLS/HLO student cohorts is held and supernumerary students are put on a waiting list. After June 17th, the course is filled-up on a first-come-first-served basis and supernumerary students are put on a waiting list.

In the case of not being able to attend one or more practical courses/lab days due to corona measures, the course coordinator will decide if the student is obligated to re-take the missed meeting and how this will take place.
 
Verplicht materiaal
Digitale leeromgeving (Brightspace)
Learning materials are made available through Brightspace, including lecture power points, working group hand-outs and practical protocols.
Aanbevolen materiaal
Boek
Useful but not obligatory books include Lehninger Principles of Biochemistry, Lodish Molecular Cell Biology and Brock Biology of Microorganisms
Werkvormen
Computerpracticum
AanwezigheidsplichtJa

Cursus
AanwezigheidsplichtJa

Practicum
AanwezigheidsplichtJa

Project
AanwezigheidsplichtJa

Sustainability certificate
AanwezigheidsplichtJa

Toetsen
Essay
Weging3
ToetsvormEssay
GelegenhedenBlok KW1, Blok KW2

Practical
Weging6
ToetsvormPracticum
GelegenhedenBlok KW1

Exam
Weging11
ToetsvormTentamen
GelegenhedenBlok KW1, Blok KW2

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