M. Guardamagna MSc (Matteo)
Promovendus - Neuroinformatica
6525 AJ NIJMEGEN
Interne postcode: 66
6500 GL NIJMEGEN
The possibility to create and store ordered sequences of events is at the base of our ability to form episodic memories. However, the cellular and circuit mechanisms governing these processes are still unclear.
In April 2018 I was awarded a Marie Curie Fellowship for Early-Stage Researchers to study hippocampal temporal dynamics, under the guidance of Prof. Francesco Battaglia and Dr. Federico Stella (as part of the M-GATE ITN Project; http://www.mgate.eu).
My research interest lies in the ability of cortical neurons to integrate information at multiple spatial and temporal scales. I combine state-of-the-art technical and computational tools to study the dorsal CA1 circuit of the hippocampus, where place cells are known to organize in complex assemblies depending on intra- and extra-hippocampal information routes.
- 2018 - 2022 - Addressing the computations of brain cortices requires a parallel investigation at multiple spatial and temporal scales. I combine advanced technological and computational tools to study temporal coding phenomena in the rodent hippocampus. During the first year of PhD I developed a new chronic implant technology for in-vivo electrophysiological recordings in mice (the Hybrid Drive). The device is capable of combining high density tetrode arrays with linear silicon probes - enabling the parallel investigation of neural activity in laminar structures and local circuits in freely moving mice. Thanks to such precision, I am currently studying hippocampal temporal coding at the single cell (phase precession) and population (theta sequences) levels. Understanding how these two mechanism interact, and how they are influenced by the same or different set of inputs, will help us understand the generation of episodic/sequential memories in the hippocampus. Meer informatie