prof. dr. J.R. Homberg (Judith)

Hoofdonderzoeker - Donders Center of Medical Neurosciences
Hoofdonderzoeker - Donders Institute for Brain, Cognition and Behaviour
Hoogleraar - Faculteit der Medische Wetenschappen (Radboudumc)

Leeropdracht: Translational Neuroscience

Contactinformatie

judith.homberg@radboudumc.nl

Bezoekadres

Kapittelweg 29
6525 EN NIJMEGEN
Interne postcode: 205

Postadres

Postbus 9101
6500 HB NIJMEGEN

Our translational animal experimental research focuses on (serotonergic) genetic and environmental factors that influence brain development and behavioural traits. Interactions between these factors may lead to maladaptive emotional responses as seen in stress-related disorders and addiction, but also cognitive improvements, depending on environmental conditions. It is our overarching hypothesis that the cognitive improvements can be used to offset the maladaptive emotional responses. To test this hypothesis we use unique mutant rats that model human genetic polymorphisms, including the serotonin transporter knockout rat. We also investigate the role of serotonin and environmental factors in brain development and long-term effects on behaviour and cognition. Our main expertise is measuring basic and complex (translational) behaviours in rats, which we combine with invasive measurements, pharmacological manipulations, in vivo neurochemical measurements and neuroimaging, molecular genetic analyses, and immunohistochemical assessments.

Onderzoeksthema

Development and lifelong plasticity

Onderzoeksgroep

Behavioural Neurogenetics

Trefwoorden: Translational neuroscience, serotonin, behaviour, vulnerability, environment

Publicaties

Belangrijke publicaties

Schipper P, Hiemstra M, Bosch K, Nieuwenhuis D, Adinolfi A, Glotzbach S, Borghans B, Lopresto D, Fernández G, Klumpers F, Hermans EJ, Roelofs K, Henckens MJAG, Homberg JR (2019) The association between serotonin transporter availability and the neural correlates of fear bradycardia. Proc Natl Acad Sci U S A. 116(51):25941-25947. Volledige tekst
Greven CU, Lionetti F, Booth C, Aron EN, Fox E, Schendan HE, Pluess M, Bruining H, Acevedo B, Bijttebier P, Homberg J (2019) Sensory Processing Sensitivity in the context of. Environmental Sensitivity: A critical review and development of research agenda.Neurosci Biobehav Rev. 98:287-305. Volledige tekst
Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR (2018) Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry. 83(12):1024-1035.
Kroeze Y, Oti M, van Beusekom E, Cooijmans RHM, van Bokhoven H, Kolk SM, Homberg JR, Zhou H (2018) Transcriptome Analysis Identifies Multifaceted Regulatory Mechanisms Dictating a Genetic Switch from Neuronal Network Establishment to Maintenance During Postnatal Prefrontal Cortex Development. Cereb Cortex. 28(3):833-851. Volledige tekst
Miceli S, Nadif Kasri N, Joosten J, Huang C, Kepser L, Proville R, Selten MM, van Eijs F, Azarfar A, Homberg JR, Celikel T, Schubert D (2017) Reduced Inhibition within Layer IV of Sert Knockout Rat Barrel Cortex is Associated with Faster Sensory Integration. Cereb Cortex. 27(2):933-949. Volledige tekst

Publicatielijsten

Meer informatie:

H-index: 34

Onderzoeksbeurzen en -prijzen

Projecten

Onderwijs

Curriculum Vitae

Nevenwerkzaamheden

Over

Judith Homberg onderzoekt factoren die invloed hebben op de ontwikkeling van het brein en gedragskenmerken. Interacties hiertussen kunnen leiden tot emotionele reacties. Ze verwacht dat interventies die ontwikkeling stimuleren deze reacties kunnen compenseren.