prof. dr. H.F. de Leeuw (Frank Erik)
Hoogleraar - Faculteit der Medische Wetenschappen (Radboudumc)
Principal Investigator - Donders Community for Medical Neuroscience
Principal Investigator - Donders Institute for Brain, Cognition and Behaviour
Reinier Postlaan 4
6525 GC NIJMEGEN
Interne postcode: 943
Frank-Erik de Leeuw is a professor in cerebrovascular disease, with an emphasis on young stroke and cerebral small vessel disease.
Clinically he works as a vascular neurologist at the department of Neurology of the Radboud University Medical Centre. His main interest in on causes and cognitive consequences of cerebrovascular disease in the young and elderly. There is a broad spectrum of cerebrovascular disease ranging from acute symptomatic intracerebral hemorrhages and cerebral infarcts to the more chronic white matter lesions and microbleeds, the latter usually going clinically unnoticed. Central in his research are clinical observations, that are being translated to an applied research question. The subsequent answers are taken back to the clinic. Cognitive and behavioral dysfunction and recovery after cerebrovascular disease are central in his research in which neuroepidemiology, neuroimaging and neuropsychology provide the methodological backbone of the often large cohorts studies that have been founded by the group.
De Leeuw is the founder and principal investigator of the
- RUNDMC study, a prospective study on causes and consequences of cerebral small vessel disease (baseline started in 2006).
- FUTURE study, the worlds’ largest study with the longest follow up on causes and consequences of young stroke (baseline started in 2009).
- ODYSSEY study, a nationwide multicenter prospective cohort study on on causes and consequences of young stroke (baseline started in 2013).
In addition he participated in several, both investigator and industry initiated, clinical trials and cohort studies (ESPRIT, PASS, DIAGRAM, MRCLEAN, PSI, PERFORM and DUST).