dr. D. Schubert (Dirk)

Universitair docent - Donders Center of Medical Neurosciences
Gastonderzoeker - Donders Institute for Brain, Cognition and Behaviour
Universitair docent - Donders Institute for Brain, Cognition and Behaviour

dr. D. Schubert (Dirk)
Werkdagen maandag, dinsdag, woensdag, donderdag, vrijdag

The scaffold of proper structural and functional organization of the neuronal networks depends on the activity of a multitude of different transcription factors, growth factors and neuromodulators during brain development. Many neurological disorders and their related cortical dysfunctions can be linked with abnormal activity of one or more factors or neuromodulators - be it because of genetic variations or because of pharmacological modulation during critical periods of brain development.

In our group, we currently focus on linking gene to neuronal network function in health and disease. To this end we investigate the structural and functional organization and maturation of the neural networks on two levels and with two translational links:

1: The role of the neuromodulator serotonin on the development of the somatosensory system (rodent model systems).
2: Epigenetic factors and neuronal network formation in models systems ( human induced pluripotent stem cell derived neuronal cultures) for intellectual disability and schizophrenia.

For our research we combine molecular, neuroanatomical, electrophysiological in vitro techniques (from single cell patch clamp over paired recordings to multielectrode array recordings), with optical stimulation (optogenetics), modelling as well as molecular assays, cell culture and behavioural approaches, partially via intense collaborations with other research groups.

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