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Drug Delivery & Formulation

In addition to drug discovery & development, pharmaceutical companies are increasingly focusing on effective and safe transport and targeted delivery of medicines such as small molecules, proteins and mRNA therapies. So-called drug delivery systems often consist of custom-made nanomaterials and transport proteins. Within the LivingLab Nanomedicine, it is possible to develop, test and visualise the drug delivery systems via state-of-the-art imaging facilities. Does the delivery system bring the drug to the right place and how quickly are the molecules broken down? These are relevant questions that are investigated within the Living Lab.

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Tagworks Pharmaceuticals is working on the development and validation of an unclick technology that will allow chemotherapy to be transported and activated on the spot in a much more targeted way. A multidisciplinary approach is necessary to develop a safe and effective chemo-delivery system. Within the Living Lab Nanomedicine, Tagworks makes use of the chemical expertise, molecular analysis techniques and a flow cabinet at the Institute for Molecules and Materials at the Radboud University. In addition, the Living Lab provides access to the Preclinical Imaging Center (PRIME) for pre-clinical imaging and validation of the delivery system.”

PharmaCytics is a pharmaceutical company with extensive knowledge in the field of medicinal chemistry and drug delivery, in particular of advanced prodrug technologies. An important area of attention is improving the oral bioavailability of medicines. The so-called nutrient-drug conjugates are of enormous value for lead compounds from fellow pharmacists. In order to validate PharmaCytics' advanced drug delivery systems, they work together with the Pharmacology & Toxicology department at Radboudumc. Here, the partners are carrying out an ex vivo study into the transport properties, absorption and bioavailability of the nutrient-drug conjugates. For this purpose, the Ussing Chamber will be used, a unique facility that also reduces the use of animal testing.”