Drug Discovery & Preclinical Drug Development

In the field of drug discovery and development - from target identification to preclinical development - the Living Lab Nanomedicine offers various services and facilities. Several research departments at Radboud University and Radboudumc as well as in the region are open to contract research and collaborative projects.

Applications

• Lead identification
• Chemical compound optimization
• High-throughput screening (Pivot Park Screening Centre)
• Molecular binding assessment (association and dissociation rates)
• Preclinical animal studies
• Kinetics & Metabolism
• Safety & Toxicology
• Bioinformation and big data analysis (see Radboudumc Technology Center Bioinformatics)
• Genome sequencing (see Radboudumc Technology Center Genomics)
• Microscopy (see Radboudumc Technology Center Microscopy)
• Mass Spectrometry (see Radboudumc Technology Center Mass Spectrometry)

Showcase

“Mercurna - a Radboudumc spinoff - is developing an mRNA-based therapy for the treatment of chronic kidney diseases. Mercurna's progress and success depends on equipment and technologies including microscopy and imaging technologies. In collaboration with the Biochemistry department at Radboudumc and the Central Animal Lab (CDL), Mercurna is able to identify critical values of its lead medicine and perform pre-clinical tests to accelerate the transition to clinical trials.”