Below you can find our mass spectrometers:
- Triple quadruple mass spectrometer UPLC/HPLC
- Orbitrap-Fusion mass spectrometer
- Biomarker validation mass spectrometer
- IRMS mass spectrometer
Triple quadruple mass spectrometer UPLC/HPLC
The triple quadruple mass spectrometer UPLC/HPLC is a facility especially well-suited for the measurement of drug concentration in biological matrices. This technique can be applied to drug development; for example for determining the appropriate dosage of medication, observing interactions with other medication, and determining the influence of nutritients on the absorption of the medication in the body.
This facility is especially of interest to the pharmaceutical industry, contract research organizations, and academic researchers who study the development of (new) drugs.
Prof. dr. David Burger
T: +31 24 36 16405
More information about this facility can be found here. You can also contact the central coordination of Radboud Research Facilities.
Orbitrap-Fusion mass spectrometer
The Orbitrap-Fusion mass spectrometer is suitable for measuring the response of small amounts of primary cells to drug medication. Possible analyses are, for example, proteome analyses, protein interaction studies, and mapping the modifications of therapeutical antibodies.
This facility is widely applicable for academic scientists and companies.
ing. Pascal Jansen
T: +31 24 36 16746
Biomarker validation mass spectrometer
This facility is based on a triple quadruple mass spectrometer with nano-/micro-scale HPLC/UPLC and is especially suitable for quantitative analysis of specific proteins and peptides in complex biological matrixes. This facility can be used for the screening of protein and peptide biomarkers in its purest form, as well as body fluids, tissue, and cells. The facility’s practical applications range from determining the concentration of disease-specific biomarkers in patient material, to the quality control of protein specimens. The method is closely aligned with other operational facilities for protein research within the Radboud Proteomics Center.
This facility is especially interesting for academic researchers, pharmaceutical, biotechnological, and food industries, and contract research organizations.
Dr. Jolein Gloerich
T: +31 24 36 16397
IRMS mass spectrometer
The measurement of isotope ratios is of great importance for various types of biogeochemical and ecological research. By means of natural abundances of stable isotopes (hydrogen, carbon, nitrogen, oxygen, sulphur, and silicon) the origin of substances containing these elements (including fertilisers, organic pollutants, and water) can be traced and the structure of food webs in natural and artificial systems can be researched. By using stable isotopes as a tracer, experimental research can be carried out on the intake and conversions of these elements by micro-organisms, plants and animals, and their behaviour in our environment.
These applications are especially of interest to companies and researchers that are concerned with water management, water technology, the agrarian sector, ecological and geothermic research, nature preservation, and consultancy.
prof. Leon Lamers
T: +31 24 36 53014