RSS00.25 Introduction to Pharmacokinetic and Pharmacodynamic Analysis

Pharmacokinetic (PK) and pharmacodynamic (PD) studies are imperative to the development of new medicines and essential in ensuring early access to medications for special populations, such as pregnant women and children. These studies allow for preliminary safety assessments, finding the appropriate dose, and evaluation of drug-drug interactions.

The course exists of four online training modules. You will gain a better understanding of how to design a pharmacokinetic/pharmacodynamic study, how to analyse pharmacology data, and how to interpret the data.

The role of clinical pharmacology has been well-established in research as well as clinical practice. Its main function in drug development is to establish a dose that is both safe and effective. In this course you will become acquainted with different techniques to describe and predict pharmacokinetics and pharmacodynamics and learn how to apply these techniques in research and clinical practice. The course is organised by the Radboudumc Pharmacy Department and supported by the Radboudumc Department of Pharmacology and Toxicology and the Radboud Center for Infectious diseases. It exists of four weekly online modules (about 10 hours per module) with an accompanying online exam.

After this course you will be able to:

1. Demonstrate a comprehensive knowledge of all fields relevant to pharmacokinetic research, understand the role of bioanalytics in PK research, and interpret and critically evaluate PK studies;
2. Describe the differences between bottom-up and top-down approaches in PK modelling, perform a physiologically-based PK modelling simulation, understand to what extent pharmacokinetics parameters can predict the pharmacodynamic properties of a drug;
3. Design a non-compartmental PK study, understand how to calculate bioequivalence, and how to derive relevant pharmacokinetic parameters answering your research question;
4. Comprehend clinical implementation of pharmacokinetics and how this can contribute to drug dosing in various populations and assessment of drug-drug interactions.

Find the detailed program here (preliminary program, can still change)