To study the complex neural networks underlying perceptual, motor and cognitive brain functions in ever greater detail, the Donders Centre for Neuroscience (DCN) has several state-of-the-art facilities, and is taking the lead in developing and implementing new techniques.
At the pre-clinical imaging facility (PRIME) of the CDL a two-photon imaging set-up is available that can be combined with behaviour and neurophysiology. The set-up consists of a Leica TCS SP5 and Chameleon Ultra II Laser system with a resonance scanner (@512x512 30 Hz).
The Drosophila facilities contain all necessary equipment for fly genetics, including 8 stereomicroscopes, fly pads, and 4 incubators. In addition, equipment to monitor Drosophila motor performance (automated negative geotaxis assay) is available, and the rooms are temperature- and light-controlled, to allow for state-of-the-art Drosophila behavioral analysis.
Translational Neuroscience Unit (TNU)
At the Translational Neurocscience Unit (TNU) in the CDL multiple behavioural set-ups are available as well as stereotaxic surgery and wet-lab facilities. Within the TNU we share expertise in behaviour, phenotyping, electrophysiology and molecular approaches.
Our researchers have access to neuroimaging facilities such as Magnetic Resonance Imaging (MRI) at 1.5, 3 and 7 Tesla, Magnetoencephalography (MEG), Electroencephalography (EEG) and Transcranial Magnetic Stimulation (TMS) which make it possible to look inside the skull - in a variety of ways.
With this measuring instrument it is possible to measure brain activity with a high temporal resolution (EEG) in combination with a reasonable (sub-cm) spatial resolution (NIRS). (more information)
Mobile auditory lab
The facility consists of two mobile eye-tracking systems that may be or may not be used in combination in a virtual acoustic environment. One of the systems is specially designed for children. (more information)
In the Neurohistology Unit all histological approaches (including cryosectioning) can be performed to explore the fascinating morphological features of nervous tissue. The Neurohistology Unit is closely coupled to the state-of-the-art microscopy facility of the General Instrumentarium (from widefield to Lightsheet microscopy) and the Neuro Culture Lab.