Davide Spalla got a eScience center fellowship and he will get 5000 EUR plus the opportunity to collaborate with their expert to redesign our neuro-analysis course. More info here https://www.esciencecenter.nl/fellowship-programme/
RNA Sequencing of the neuromuscular junction to evaluate the role of skeletal muscle gene expression in FUS-associated amyotrophic lateral sclerosis (ALS)Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neurodegenerative disease, resulting in paralysis and death due to respiratory failure. ALS is an incurable disease, with only two FDA-approved drugs which only marginally extend survival without affecting disease progression. In order to develop future therapeutic approaches that could block the onset or the progression of ALS we must identify the molecular derailments leading to the pathology. In the project, we will investigate the role of skeletal muscle in the pathogenesis of ALS and by using cutting-edge subcellular RNA sequencing approaches, identify potential therapeutic targets in this tissue. The project will resolve an ongoing debate in the field: does skeletal muscle contribute to ALS pathogenesis? Main applicant: Anne WienandResearch institutes involved: DCN, RIMLS
The Netherlands Organisation for Scientific Research (NWO) awarded Fleur Zeldenrust and and Martin Vinck a Vidi grant of 800,000 euros. This will allow them to develop an innovative line of research and build up their own research group for the next five years.
On the path of green: science with a light footprint Anne Wienand Donders Institute. 2022 Honorable Mention In this photo, we can see an ALS mouse, a neurodegenerative model characterized by impairments of the motor system, exploring the CatWalk. This task uses the play of colors to help us detect the footprints of mice and test gait and locomotion. Provokingly, the mouse there evokes the construct of walking on a green track with light footprints, which resonates with the idea of diminishing the negative impact of animal research. As in the photo, even a light footprint on a green path still requires animal research, and it is as important to acknowledge this as it is to move towards more sustainable science.
The Swiss National Science Foundation has awarded a postdoc fellowship to María Landínez Macías to conduct her research in the Lab of Prof. Dr. Erik Storkebaum. Her project aims at dissecting molecular mechanisms of Charcot Marie Tooth (CMT) disease, and subsequently use this knowledge to develop therapeutic applications.