Interdisciplinary Research Platform Voucher awarded to Anne Wienand

Date of news: 4 July 2022
  • RNA Sequencing of the neuromuscular junction to evaluate the role of skeletal muscle gene expression in FUS-associated amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neurodegenerative disease, resulting in paralysis and death due to respiratory failure. ALS is incurable and there is a clear unmet medical need, which is attributable to the incomplete understanding of the molecular pathogenesis of ALS.  In order to develop future therapeutic approaches that could block the onset or the progression of ALS we must identify the molecular derailments leading to the pathology. In the project, we will investigate the role of skeletal muscle in the pathogenesis of ALS and by using cutting-edge subcellular RNA sequencing approaches, identify potential therapeutic targets in this tissue. The project will resolve an ongoing debate in the field: does skeletal muscle contribute to ALS pathogenesis?
    • Main applicant: Anne Wienand
    • Research institutes involved: DCN, RIMLS
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