Research Highlights
Galectins are carbohydrate binding proteins expressed by a wide variety of cells. They can be secreted to the extracellular space or be located in the cytoplasm or the nucleus. Radboud Consortium for Glycoscience researchers have uncovered a novel function for galectin-9 in the intracellular trafficking of cytokines in dendritic cells.
Immunoprecipitation coupled with mass spectrometry revealed that galectin-9 molecularly interacts with the SNARE protein Vamp-3 and immunological and biochemistry readouts identified that galectin-9 was required for rerouting Vamp-3-containing endosomes upon DC activation and postulated galectin-9 as a necessary mechanistic component for intracellular trafficking.
Check out the full publication via https://link.springer.com/article/10.1007/s00018-023-04954-x.
Events
Minisymposium - Glyans in onco-immunology
The glycome has a major impact on every aspect of human biology and disease. This symposium gathers (inter)national leading scientists to provide an overview on current advances in the field of glyco-immunology, with a special interest on anti-tumour immune responses and the impact of glycans in novel therapeutics.
