Bártfai team

Research

Malaria, caused by eukaryotic parasites of the Plasmodium genus, claims the life of about half a million people every year, the majority of whom are children or pregnant women. Although gene regulatory, and in particular epigenetic, mechanism unique to the parasite could provide potential targets for drug-based intervention, we know very little about these processes. My group aims to decipher transcriptional and epigenetic mechanisms that govern the development of P. falciparum and its interaction with the human host. We use state-of-the-art genomic (e.g. ChIP-seq, ATAC-seq, single-cell RNA-seq) and quantitative proteomic (e.g. DiQ-BioID) approaches to collect high quality data about the Plasmodium epigenome, transcriptome and proteome. Integrative analysis of these datasets together with complementary sets of biochemical and functional experiments will provide important insights into gene regulatory mechanism of the malaria parasite and clues for the development of antimalarial compounds.

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