Vermeulen team


Michiel Vermeulen
Research

The development of an adult human being from a single fertilized egg is accompanied by the generation of ~200 functionally distinct cell types. Each of these cell types expresses only a subset of the 20.000 genes that the human genome encodes for. Cell-type specific gene expression patterns thus ensure the generation of hundreds of phenotypes based on a single genotype. Transcription factors play an important role in driving cell-type specific gene expression, but so-called epigenetic modifications of DNA and core histones also regulate changes in gene expression and phenotype during development and during adult life. Our lab develops and applies state-of-the-art quantitative mass-spectrometry based (interaction) proteomics and next generation DNA sequencing technology to decipher (epi)genetic regulation of gene expression in  (differentiated) stem cells. Furthermore, we use the same technology to study deregulation of gene expression in cancer. To address our central research questions, we make use of embryonic- and adult stem cell based in vitro cell culture models, including gastruloids and (cancer) organoids, and primary cells.

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TEAM MEMBERS

Nelleke Bos-Spruijt
Postdoc

Vicky Luna Velez
Postdoc

Aniek Martens
PhD student

Suzan Stelloo
Postdoc

Kasia Kliza
Postdoc

Inge de Krijger
Postdoc

Cathrin Gräwe
PhD student

Jelmer Dijkstra
PhD student

Hannah Neikes
PhD student

Dick Zijlmans
PhD student

Roel Wester
PhD student

Marijke Baltissen
Technician

Lieke Lamers
Technician

Pascal Jansen
Technician

Suzanne Weijers
PhD student

Marìa Teresa Alejo Vinogradova
PhD student

Eugenia Passaro
PhD student

Balaji Srinivasan 
Postdoc

Miguel Hernández-Quiles
Postdoc