Zhou team

ResearchJo Zhou

Proper development of the embryo requires orchestrated regulation of gene expression in a temporal and spatial manner. Disruption of gene regulation during embryonic development leads to developmental disorders. My research program aims at elucidating molecular mechanisms underlying cell fate decisions in development and related disease, using systems biology approaches. In addition, my team applies the molecular insights for stem cell manipulation, tissue regeneration, disease genetics and therapeutic development. Three major research lines within my research theme:

1) understand cell fate determination of epithelial development and disease;

2) develop complex tissue models to dissect cell fate determination;

3) dissect disease mechanisms and explore therapeutic options for these diseases.

Several patient-derived stem cell models are established in my team: induced pluripotent stem cells (iPSCs) that can be differentiated into disease-relevant lineages, and adult epidermal stem cells and corneal limbal stem cells. Using these patient-derived model systems and state-of-the-art epigenomics approaches, my group identifies gene regulatory networks including genes and regulatory elements that control normal developmental processes and de-regulated circuitries that are relevant to diseases, thereby elucidating disease mechanisms.

Useful links:

TEAM MEMBERS

Jos Smits
PhD student

Felicitas Pardow
PhD student

Quan Xu
PhD student

Luca Meesters
PhD student

Julian Arts
PhD student

Dulce de Lima Cunha
Postdoc

Camille Laberthonnière
Postdoc