FGF receptor targeting causes craniofacial malformation

Date of news: 17 December 2022

Pharmacological targeting of FGFR1-4 kinase signaling causes severe craniofacial malformations in zebrafish larvae, whereas abrogation of FGFR2 kinase signaling alone does not induce craniofacial skeletal abnormalities. These findings were recently published by researchers from Dentistry (Radboudumc) and Animal Ecology and Physiology (Radboud University). The results will further the understanding of the role of FGFRs in the etiology of craniofacial malformations.

Link to the full text of the paper can be found here.