Publications
2021:
Lrp5 Mutant and Crispant Zebrafish Faithfully Model Human Osteoporosis, Establishing the Zebrafish as a Platform for CRISPR‐Based Functional Screening of Osteoporosis Candidate Genes. J Bone Miner Res. (2021) Bek JW, Shochat C, Clercq AD, Saffel HD, Boel A, Metz J, Rodenburg F, Karasik D, Willaert A, Coucke PJ https://doi.org/10.1002/jbmr.4327
Stress Impairs Skin Barrier Function and Induces α2-3 Linked N-Acetylneuraminic Acid and Core 1 O-Glycans on Skin Mucins in Atlantic Salmon, Salmo salar. Int J Mol Sci (2021) Benktander J, Sundh H, Sundell K, Murugan AVM, Venkatakrishnan V, Padra JT, Kolarevic J, Terjesen BF, Gorissen M, Lindén SK https://doi.org/10.3390/ijms22031488
Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations. Mol Ther (2021) Dulla K, Slijkerman R, Diepen HC van, Albert S, Dona M, Beumer W, Turunen JJ, Chan HL, Schulkens IA, Vorthoren L, Besten C den, Buil L, Schmidt I, Miao J, Venselaar H, Zang J, Neuhauss SCF, Peters T, Broekman S, Pennings R, Kremer H, Platenburg G, Adamson P, Vrieze E de, Wijk E van https://doi.org/10.1016/j.ymthe.2021.04.024
Identification of novel biomarkers for pyridoxine-dependent epilepsy using untargeted metabolomics and infrared ion spectroscopy - biochemical insights and clinical implications. Medrxiv (2021) Engelke UFH, Outersterp RE van, Merx J, Geenen FAMG van, Rooij A van, Berden G, Huigen MCDG, Kluijtmans LAJ, Peters TMA, Al-Shekaili HH, Leavitt BR, Vrieze E de, Broekman S, Wijk E van, Tseng LA, Kulkarni P, Rutjes FPJT, Mecinović J, Struys EA, Jansen LA, Gospe SM, Mercimek-Andrews S, Hyland K, Willemsen MAAP, Bok LA, Karnebeek CDM van, Wevers RA, Boltje TJ, Oomens J, Martens J, Coene KLM https://doi.org/10.1101/2021.01.22.20248925
Endoplasmic Reticulum Stress as a Key Mechanism in Stunted Growth of Seawater Rainbow Trout (Oncorhynchus Mykiss). Research Square (2021) Morro B, Broughton R, Balseiro P, Handeland SO, Mackenzie S, Doherty MK, Whitfield PD, Shimizu M, Gorissen M, Sveier H, Albalat A https://doi.org/10.21203/rs.3.rs-527369/v1
Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish. Commun Biology (2021) Quint WH, Tadema KCD, Vrieze E de, Lukowicz RM, Broekman S, Winkelman BHJ, Hoevenaars M, Gruiter HM de, Wijk E van, Schaeffel F, Meester-Smoor M, Miller AC, Willemsen R, Klaver CCW, Iglesias AI https://doi.org/10.1038/s42003-021-02185-z
2020:
The transcriptome of regenerating zebrafish scales identifies genes involved in human bone disease. Biorxiv (2020) Bergen DJM, Tong Q, Shukla A, Newman E, Zethof J, Lundberg M, Ryan R, Youlten SE, Zeggini E, Croucher PI, Flik G, Richardson RJ, Kemp JP, Hammond CL, Metz JR https://doi.org/10.1101/2020.10.08.331561
Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae. Front Immunol (2020) Bos R van den, Cromwijk S, Tschigg K, Althuizen J, Zethof J, Whelan R, Flik G, Schaaf https://doi.org/10.3389/fimmu.2020.00727
Behavioral research in zebrafish (Danio rerio): strain as source of variation. Behavioral and Neural Genetics of Zebrafish (2020) Bos R van den, Flik G, Gorissen M https://doi.org/10.1016/b978-0-12-817528-6.00015-2
Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish. Epigenet Chromatin (2020) Broeder MJ den, Ballangby J, Kamminga LM, Aleström P, Legler J, Lindeman LC, Kamstra JH. https://doi.org/10.1186/s13072-020-0329-y
Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics. Endocrine-related cancer (2020) Dona M, Waaijers S, Richter S, Eisenhofer G, Korving J, Kamel SM, Bakkers J, Rapizzi E, Rodenburg RJ, Zethof J, Gorissen M, Flik G, Deen PMT, Timmers HJ https://doi.org/10.1530/erc-20-0308
The anti-epileptic drug valproic acid causes malformations in the developing craniofacial skeleton of zebrafish larvae. Mech Develop (2020) Gebuijs IGE, Metz JR, Zethof J, Carels CEL, Wagener FADTG, Hoff JWV den https://doi.org/10.1016/j.mod.2020.103632
Are acute and acclimated thermal effects on metabolic rate modulated by cell size? A comparison between diploid and triploid zebrafish larvae. J Exp Biol (2020) Hermaniuk A, Pol ILE van de, Verberk WCEP https://doi.org/10.1242/jeb.227124
Modeling ZNF408-Associated FEVR in Zebrafish Results in Abnormal Retinal Vasculature. Invest Ophth Vis Sci (2020) Karjosukarso DW, Ali Z, Peters TA, Zhang JQC, Hoogendoorn ADM, Garanto A, Wijk E van, Jensen LD, Collin RWJ https://doi.org/10.1167/iovs.61.2.39
Triploidy in zebrafish larvae: Effects on gene expression, cell size and cell number, growth, development and swimming performance. Plos One (2020) Pol ILE van de, Flik G, Verberk WCEP https://doi.org/10.1371/journal.pone.0229468
Clinical and preclinical therapeutic outcome metrics for USH2A-related disease. Hum Mol Genet (2020) Toms M, Dubis AM, Vrieze E de, Tracey-White D, Mitsios A, Hayes M, Broekman S, Baxendale S, Utoomprurkporn N, Bamiou D, Bitner-Glindzicz M, Webster AR, Wijk EV, Moosajee M https://doi.org/10.1093/hmg/ddaa004
Water temperature affects osmoregulatory responses in gilthead sea bream (Sparus aurata L.). J Therm Biol (2020) Vargas-Chacoff L, Arjona FJ, Ruiz-Jarabo I, García-Lopez A, Flik G, Mancera JM https://doi.org/10.1016/j.jtherbio.2020.102526
Pannexin‐1 mediates fluid shear stress‐sensitive purinergic signaling and cyst growth in polycystic kidney disease. Faseb J (2020) Verschuren EHJ, Rigalli JP, Castenmiller C, Rohrbach MU, Bindels RJM, Peters DJM, Arjona FJ, Hoenderop JGJ https://doi.org/10.1096/fj.201902901r